Andrea Sarto studied composition and electronic music with Gian Paolo Luppi, Paolo Aralla, and Lelio Camilleri at the Martini Conservatory in Bologna. He went on to study composition with Ivan Fedele at the Santa Cecilia Academy in Rome, and was invited to attend classes at the Kungliga Musikhögskolan in Stockholm as a guest student. In 2012, he completed IRCAM's composition and computer music course, under the supervision of Yan Maresz and Mauro Lanza.

Sarto's works have been performed in Italy (including at the Venice Biennale, TempoReale Festival, Stresa Settimane Musicali, Exitime Festival, Festival di Nuova Consonanza, and Milano Musica) and in Europe (Huddersfield festival, Faithful festival in Berlin, Gaudeamus Music Week in Amsterdam, Ostrava Music Days), and Sweden, by ensembles and orchestras such as FontanaMix Ensemble, Kreutzer Quartet, Doelen Kwartet, Orchestre National de Lorraine, Helsingborgsymfonieorkester, Algoritmo Ensemble, Holland Symfonia, and the Gävle Symphony Orchestra.

He participated in the Malmö Orchestral Workshop, Sweden (2006), Centre Acanthes in Metz (2006 and 2009), Stresa EAR-Lab with Luca Francesconi (2006), and Royaumont Voix Nouvelles with Brian Ferneyhough, Jérôme Combier and Xavier Dayer (2008). He also collaborated with the recorder and cello classes of Antonio Politano (HEMU Lausanne) and Francesco Dillon (Fiesole Academy of Music), respectively. In 2010, he was guest composer-in-residence at Royaumont for the Transforme Project, in which composers of electronic music collaborated with dancers/choreographers. In 2017–2020, he was composer-in-residence at the Municipal Conservatory of the 10th arrondissement of Paris and, in 2023–2024, at Villa Rohannec'h, where he wrote Traversée I, Traversée II and Traversée III.

Andrea Sarto was a finalist in the International Gaudeamus Composer Competition in 2007 and 2009, the Barzio Fourth National Competition for Young Composers in 2001, and the Bologna Iceberg Competition in 2007. Several of his works have been broadcast on RAI Radio 3 and published online by the Miraloop independent label.

Since 2019, he has been teaching electronic music at the Conservatoire de Marne-et-Gondoire (Bussy-Saint-Georges). In 2022 and 2023, he taught music writing at the University of Évry-Paris-Saclay.

He is a member of the /nu/thing collective founded in 2012, alongside Daniele Ghisi, Eric Maestri and Andrea Agostini.

Some of his works are published by Impronta Verlag.